Review




Structured Review

Gilead Sciences sars cov 2 replication transcription complex
Sars Cov 2 Replication Transcription Complex, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 15646 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/VEKLURY/emdb_26639-0-19-24
Average 99 stars, based on 15646 article reviews
sars cov 2 replication transcription complex - by Bioz Stars, 2026-10
99/100 stars

Images

Related Articles

other:

Article Title: Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection.
Article Snippet: Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir.

Inhibition:

Article Title: Characterization, Directed Evolution, and Targeting of DNA Virus-Encoded RNA Capping Enzymes Using Phenotypic Yeast Platforms.
Article Snippet: The constant and the sudden emergence of zoonotic human and animal viruses is a significant threat to human health, the world economy, and the world food supply.. This has necessitated the development of broad-spectrum therapeutic strategies to combat these emerging pathogens.. Mechanisms that are essential for viral replication and propagation have been successfully targeted in the past to develop broad-spectrum therapeutics that can be readily repurposed to combat new zoonotic pathogens.

Article Title: Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1.
Article Snippet: .. The concentrations of RetroMAD1 that demonstrated equally effective inhibition of SARS-CoV-2 replication as Remdesivir at 0.1 μg/ mL are in italics. a Titer results originate from the virus yield reduction assay. b EC90 denotes the 90% effective concentration, which is the concentration required to reduce virus yield by 1 − log10, as determined through regression analysis. .. Test compounds Concentration (μg/mL) aLog10 CCID50 virus per 0.2 mL bEC90 (μg/mL) RetroMAD1 400 2.5 157 300 2.67 200 3.5 150 3.67 100 3.67 75 4 50 4.3 37.5 4 Remdesivir 1 1.67 0.006 0.1 2.67 0.01 3.5 0.001 3.67 Virus control NA 4.4 NA 10 Vol:. (1234567890) Scientific Reports | (2023) 13:20178 | https://doi.org/10.1038/s41598-023-47511-z Subsequently, we conducted in vitro experiments, including a 3CL protease inhibitory assay and the use of human-derived TBE cells through EpiAirway Model, which provided additional compelling evidence of RetroMAD1’s effectiveness in preventing SARS-CoV-2 infection.

Virus:

Article Title: Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1.
Article Snippet: .. The concentrations of RetroMAD1 that demonstrated equally effective inhibition of SARS-CoV-2 replication as Remdesivir at 0.1 μg/ mL are in italics. a Titer results originate from the virus yield reduction assay. b EC90 denotes the 90% effective concentration, which is the concentration required to reduce virus yield by 1 − log10, as determined through regression analysis. .. Test compounds Concentration (μg/mL) aLog10 CCID50 virus per 0.2 mL bEC90 (μg/mL) RetroMAD1 400 2.5 157 300 2.67 200 3.5 150 3.67 100 3.67 75 4 50 4.3 37.5 4 Remdesivir 1 1.67 0.006 0.1 2.67 0.01 3.5 0.001 3.67 Virus control NA 4.4 NA 10 Vol:. (1234567890) Scientific Reports | (2023) 13:20178 | https://doi.org/10.1038/s41598-023-47511-z Subsequently, we conducted in vitro experiments, including a 3CL protease inhibitory assay and the use of human-derived TBE cells through EpiAirway Model, which provided additional compelling evidence of RetroMAD1’s effectiveness in preventing SARS-CoV-2 infection.

Article Title: Novel Molecular Consortia of Cannabidiol with Nonsteroidal Anti-Inflammatory Drugs Inhibit Emerging Coronaviruses’ Entry
Article Snippet: Currently, in the European Union, several drugs have been approved for the treatment of COVID-19: remdesivir (Gilead Sciences, Foster City, CA, USA), PF-07321332, and ritonavir (Pfizer, New York, NY, USA), and monoclonal antibodies, such as sotrovimab (GlaxoSmitkKline, Brentford, UK), casirivimab/imdevimab (Roche, Basel, Switzerland), regdanvimab (Celltrion, Yeonsu-gu, Republic of Korea), and tixagevimab/cilgavimab (AstraZeneca, Cambridge, UK) [ ]. .. However, it should be highlighted that all the above-mentioned therapeutics (i) act directly against SARS-CoV-2 replication, i.e., remdesivir [ ], PF-07321332, and ritonavir [ ], or (ii) block virus entry to the host cells, i.e., monoclonal antibodies [ ], and should be implemented as part of therapy within 1–5 days of the onset of symptoms to mitigate virus replication, spread, and pathogenesis, and to block the SARS-CoV-2-mediated overreaction of the immune system, which leads to severe acute respiratory syndrome. ..

Concentration Assay:

Article Title: Inhibition of SARS-CoV-2 3CL protease by the anti-viral chimeric protein RetroMAD1.
Article Snippet: .. The concentrations of RetroMAD1 that demonstrated equally effective inhibition of SARS-CoV-2 replication as Remdesivir at 0.1 μg/ mL are in italics. a Titer results originate from the virus yield reduction assay. b EC90 denotes the 90% effective concentration, which is the concentration required to reduce virus yield by 1 − log10, as determined through regression analysis. .. Test compounds Concentration (μg/mL) aLog10 CCID50 virus per 0.2 mL bEC90 (μg/mL) RetroMAD1 400 2.5 157 300 2.67 200 3.5 150 3.67 100 3.67 75 4 50 4.3 37.5 4 Remdesivir 1 1.67 0.006 0.1 2.67 0.01 3.5 0.001 3.67 Virus control NA 4.4 NA 10 Vol:. (1234567890) Scientific Reports | (2023) 13:20178 | https://doi.org/10.1038/s41598-023-47511-z Subsequently, we conducted in vitro experiments, including a 3CL protease inhibitory assay and the use of human-derived TBE cells through EpiAirway Model, which provided additional compelling evidence of RetroMAD1’s effectiveness in preventing SARS-CoV-2 infection.

Blocking Assay:

Article Title: Novel Molecular Consortia of Cannabidiol with Nonsteroidal Anti-Inflammatory Drugs Inhibit Emerging Coronaviruses’ Entry
Article Snippet: Currently, in the European Union, several drugs have been approved for the treatment of COVID-19: remdesivir (Gilead Sciences, Foster City, CA, USA), PF-07321332, and ritonavir (Pfizer, New York, NY, USA), and monoclonal antibodies, such as sotrovimab (GlaxoSmitkKline, Brentford, UK), casirivimab/imdevimab (Roche, Basel, Switzerland), regdanvimab (Celltrion, Yeonsu-gu, Republic of Korea), and tixagevimab/cilgavimab (AstraZeneca, Cambridge, UK) [ ]. .. However, it should be highlighted that all the above-mentioned therapeutics (i) act directly against SARS-CoV-2 replication, i.e., remdesivir [ ], PF-07321332, and ritonavir [ ], or (ii) block virus entry to the host cells, i.e., monoclonal antibodies [ ], and should be implemented as part of therapy within 1–5 days of the onset of symptoms to mitigate virus replication, spread, and pathogenesis, and to block the SARS-CoV-2-mediated overreaction of the immune system, which leads to severe acute respiratory syndrome. ..

Expressing:

Article Title: Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression.
Article Snippet: The G-quadruplex (G4) formed in single-stranded DNAs or RNAs plays a key role in diverse biological processes and is considered as a potential antiviral target.. In the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 25 putative G4-forming sequences are predicted; however, the effects of G4-binding ligands on SARS-CoV-2 replication have not been studied in the context of viral infection.. In this study, we investigated whether G4-ligands suppressed SARSCoV-2 replication and whether their antiviral activity involved stabilization of viral RNA G4s and suppression of viral gene expression.

Article Title: Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids.
Article Snippet: The effect of Remdesivir, the well-established clinical drug for treating COVID-19 [67,68], was also evaluated in another parallel incubation of iPSC-AOs (Supplemental Fig. 4A). .. Immunoblotting and immunofluorescence showed that preincubation of Remdesivir reduced SARS-CoV-2 N protein expression in infected iPSC-AOs (Supplemental Fig. 4B & C), indicating the repression of SARS-CoV-2 replication by Remdesivir. ..

Western Blot:

Article Title: Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids.
Article Snippet: The effect of Remdesivir, the well-established clinical drug for treating COVID-19 [67,68], was also evaluated in another parallel incubation of iPSC-AOs (Supplemental Fig. 4A). .. Immunoblotting and immunofluorescence showed that preincubation of Remdesivir reduced SARS-CoV-2 N protein expression in infected iPSC-AOs (Supplemental Fig. 4B & C), indicating the repression of SARS-CoV-2 replication by Remdesivir. ..

Immunofluorescence:

Article Title: Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids.
Article Snippet: The effect of Remdesivir, the well-established clinical drug for treating COVID-19 [67,68], was also evaluated in another parallel incubation of iPSC-AOs (Supplemental Fig. 4A). .. Immunoblotting and immunofluorescence showed that preincubation of Remdesivir reduced SARS-CoV-2 N protein expression in infected iPSC-AOs (Supplemental Fig. 4B & C), indicating the repression of SARS-CoV-2 replication by Remdesivir. ..

Infection:

Article Title: Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids.
Article Snippet: The effect of Remdesivir, the well-established clinical drug for treating COVID-19 [67,68], was also evaluated in another parallel incubation of iPSC-AOs (Supplemental Fig. 4A). .. Immunoblotting and immunofluorescence showed that preincubation of Remdesivir reduced SARS-CoV-2 N protein expression in infected iPSC-AOs (Supplemental Fig. 4B & C), indicating the repression of SARS-CoV-2 replication by Remdesivir. ..



Similar Products

96
Sino Biological viral replication cycle
Viral Replication Cycle, supplied by Sino Biological, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/SARS-CoV-2+(2019-nCoV)+Nucleocapsid-His+recombinant+Protein/pmc12656851-57-19-67
Average 96 stars, based on 1 article reviews
viral replication cycle - by Bioz Stars, 2026-10
96/100 stars
  Buy from Supplier

99
Gilead Sciences sars cov 2 replication transcription complex
Sars Cov 2 Replication Transcription Complex, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/VEKLURY/emdb_26639-0-19-24
Average 99 stars, based on 1 article reviews
sars cov 2 replication transcription complex - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier

99
Gilead Sciences sars cov 2 replication
Sars Cov 2 Replication, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/VEKLURY/pm40716470-171-11-13
Average 99 stars, based on 1 article reviews
sars cov 2 replication - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier

86
Pfizer Inc vaccine name composition vaccine type genetic material replication mechanism 1 pfizer comirnaty sars cov 2 spike mrna mrna mrna
Vaccine Name Composition Vaccine Type Genetic Material Replication Mechanism 1 Pfizer Comirnaty Sars Cov 2 Spike Mrna Mrna Mrna, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/comirnaty+vaccine/10__33225_slash_jbse_slash_25__24__465-500-1-11
Average 86 stars, based on 1 article reviews
vaccine name composition vaccine type genetic material replication mechanism 1 pfizer comirnaty sars cov 2 spike mrna mrna mrna - by Bioz Stars, 2026-10
86/100 stars
  Buy from Supplier

99
Gilead Sciences remdesivir inhibited sars cov 2 replication
Remdesivir Inhibited Sars Cov 2 Replication, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/VEKLURY/pm38723907-142-0-0
Average 99 stars, based on 1 article reviews
remdesivir inhibited sars cov 2 replication - by Bioz Stars, 2026-10
99/100 stars
  Buy from Supplier

90
Pasteur Institute replication-competent vesicular stomatitis virus rvsv-egfp-sars-cov-2-sδ21
Replication Competent Vesicular Stomatitis Virus Rvsv Egfp Sars Cov 2 Sδ21, supplied by Pasteur Institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/sars+cov+2+virus/pm38804187-32-24-36
Average 90 stars, based on 1 article reviews
replication-competent vesicular stomatitis virus rvsv-egfp-sars-cov-2-sδ21 - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

90
Janssen recombinant, replication-incompetent adenovirus type 26 expressing the sars-cov-2 spike protein vaccine
Recombinant, Replication Incompetent Adenovirus Type 26 Expressing The Sars Cov 2 Spike Protein Vaccine, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/ad+26+cov2+s/us11938182-174-34-40
Average 90 stars, based on 1 article reviews
recombinant, replication-incompetent adenovirus type 26 expressing the sars-cov-2 spike protein vaccine - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

90
MyBiosource Biotechnology replication-deficient mlv pseudotyped particles sars-cov-2 spike protein carrying d614 genotype
Replication Deficient Mlv Pseudotyped Particles Sars Cov 2 Spike Protein Carrying D614 Genotype, supplied by MyBiosource Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sars+cov+2+replication/human+novel+coronavirus++sars+cov+2++neutralizing+antibody+elisa+kit/pm38257782-87-36-39
Average 90 stars, based on 1 article reviews
replication-deficient mlv pseudotyped particles sars-cov-2 spike protein carrying d614 genotype - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

Image Search Results